Genetics of Glioblastoma

Gene deletion of NFKBIA, on chromosome 14, causes Hodgkin’s lymphoma, multiple myeloma, melanoma, and breast, lung, colon cancer and glioblastoma. NFKBIA, deletions causes changes of the epidermal growth factor receptor, or EGFR. NFKBIA deletion causes increases in NF-kappa-B because it’s activity is not reduced by the lack of I-kappa-B in the cell. EGFR hyperactivity and NF-kappa-B activity results in glioblastoma formation.

Reference: http://www.nejm.org/doi/full/10.1056/NEJMoa1006312#t=abstract