Researchers have found that ABCB4 gene, is defective in patients with high cholesterol thus leading to an impairment in the transport of fats from the liver into bile to facilitate removal of cholesterol from the body. Defective ABCB4 protein was found to impair cholesterol excretion & caused bad cholesterol to accumulate.
Reference:
Michael C. Mahaney, Ph.D., Rampratap S. Kushwaha, Ph.D., and Jane F. VandeBerg,Chan et al.. ABCB4 mediates diet-induced hypercholesterolemia in laboratory opossums. The Journal of Lipid Research
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