Genetics of a Migraine

A new study has shown that the accumulation of brain glutamate levels in nerve cell junctions (synapses) causes the initiation of a migraine.

DNA variant on Chromosome 8 between two genes -- PGCP and MTDH/AEG-1 -- have a greater risk for developing migraine

MTDH/AEG-1 regulates the EAAT2 gene: the protein responsible for clearing glutamate from brain synapses.

Reference:
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