Angiogenesis(formation of new blood vessels) with abnormal shape occurs when there is a oxygen shortage from cancer metastasis tumor growth. Researchers have found that Histidine-rich glycoprotein (HRG) helps in the normalization of tumor blood vessels and therefore is a new mechanism for cancer therapy.
Reference:
Charlotte Rolny, Massimiliano Mazzone, Sònia Tugues, Damya Laoui, Irja Johansson, Cathy Coulon, Mario Leonardo Squadrito, Inmaculada Segura, Xiujuan Li, Ellen Knevels. HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF. Cancer Cell
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