The precuneus(a anatomical structure in the brain) develops amyloid deposits for patients with Alzheimer's disease and in pre-Alzheimer's . APOE4 is the major genetic risk factor for sporadic causes of developing Alzheimer's disease.
References:
Y. I. Sheline, J. C. Morris, A. Z. Snyder, J. L. Price, Z. Yan, G. D'Angelo, C. Liu, S. Dixit, T. Benzinger, A. Fagan, A. Goate, M. A. Mintun. APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42. Journal of Neuroscience
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