Changes in the genetics causing reduced C/EPB-beta expression raised the activity of CITED4. As a result, heart cells called cardiomyocytes increasingly divide and grow in size to similar levels of an athlete. Lowering C/EPB-beta expression protected mice from developing heart failure.
References:
Pontus Boström, Nina Mann, Jun Wu, Pablo A. Quintero, Eva R. Plovie, Daniela Panáková, Rana K. Gupta, Chunyang Xiao, Calum A. MacRae, Anthony Rosenzweig, Bruce M. Spiegelman. C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling. Cell
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