P-Rex1 is overexpressed breast cancer patients leading to increased chances of developing metastasis. Estrogen-receptor signaling and CXCR4 also also appears to rely on P-Rex1, indicating small molecule inhibitors that block proteins in the Rac pathway may help in developing medicines to treat breast cancer. For example, inhibition of P-Rex1 might improve responses tamoxifen efficacy.
Reference:
Maria Soledad Sosa, Cynthia Lopez-Haber, Chengfeng Yang, HongBin Wang, Mark A. Lemmon, John M. Busillo, Jiansong Luo, Jeffrey L. Benovic, Andres Klein-Szanto, Hiroshi Yagi, J. Silvio Gutkind, Ramon E. Parsons, Marcelo G. Kazanietz. Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer. Molecular Cell, Volume 40, Issue 6, 877-892, 22 December 2010
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