New research has found that overproduction of Regulator of Calcineurin 1 (RCAN1), caused by stroke, hypertension or the presence of beta amyloid leads to neuronal atrophy in the hippocampus and cortex in people with Down Syndrome and Alzheimer's Disease.
Reference:
X. Sun, Y. Wu, B. Chen, Z. Zhang, W. Zhou, Y. Tong, J. Yuan, K. Xia, H. Gronemeyer, R. A. Flavell, W. Song. Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase 3 activation. Journal of Biological Chemistry
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