Salt-inducible kinase 2 (SIK2) reduced cAMP responsive elements binding protein (CREB). CREB is a protein that protects neurons after ischemia. Oxygen and glucose deprivation causes decreased CREB function. The study found neurons that lacked SIK2 had increased function after ischemia.
Reference:
Tsutomu Sasaki et al. SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB. Neuron
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