Precise inhibition of Robo4(found only in hematopoietic stem cells & in endothelial cells of blood vessels) may lead to mobilization of hematopoietic stem cells. Hematopoietic stem cells use Robo4 to anchor themselves in the bone marrow.
Reference:
Stephanie Smith-Berdan, Andrew Nguyen, Deena Hassanein, Matthew Zimmer, Fernando Ugarte, Jesús Ciriza, Dean Li, Marcos E. García-Ojeda, Lindsay Hinck, E. Camilla Forsberg. Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches. Cell Stem Cell,
