A gene - MKP-1 was increased in the brain tissues of depressed individuals. A study showed that when the MKP-1 gene is stopped the mice become resilient to stress. However, when the gene is activated, mice exhibit symptoms that similar to depression
Reference:
Vanja Duric, Mounira Banasr, Pawel Licznerski, Heath D Schmidt, Craig A Stockmeier, Arthur A Simen, Samuel S Newton, Ronald S Duman. A negative regulator of MAP kinase causes depressive behavior. Nature Medicine
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